Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. Jacksonville / Northeast Florida
  4. Jacksonville
  5. Jacksonville
M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.8
4.8
449 Reviews
$50 and over
Seafood

Make a reservation

2 people
11:00 PM
Booked 11 times today
Experiences are available.
  • Good for special occasions
  • Good for business meals
  • Innovative
Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers, Chef Matthew and David Medure. Our menu has a focus on fresh seafood with an Asian and Mediterranean flair. Visit our lounge for a craft cocktail or select a bottle of wine from our extensive list. Serving Lunch and Dinner Monday - Saturday.

Dining areas

Additional information

  • Dining style
    Fine Dining
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Phone number
    (904) 953-0409
  • Dress code
    Casual Dress

Experiences

  • 11/16 Winemaker Dinner: Bellaria Winery

    $140.25 per person

    Prepaid

    Nov 16, 2024 only
    Join us for a Winemaker Dinner: Bellaria Winery on November 16th! Enjoy a four-course meal expertly paired with exquisite wines from the Maffei family, who have deep roots in Roccabascerana, nestled between the scenic Partenio Park and the Sabato and Calore valleys. Discover native varieties like Greco di Tufo DOCG and Taurasi DOCG, crafted using ancient natural processes. As you savor each dish, the winemaker will share insights about the wines, all of which will be available for purchase that evening. There is only one seating at 6:30 PM. With limited reservations available, reserve your spot today for $140.24 inclusive of tax and tip per person. Celebrate a perfect blend of culinary delight and winemaking passion!
  • 11/23 Morocco "Grows Together/Goes Together"

    $90.00 - $135.00 per person

    Nov 23, 2024 only
    Join us at M Brothers on Saturday, November 23, 2024, for an unforgettable culinary experience! Indulge in a 4-course tasting menu inspired by the vibrant flavors of Morocco! This experience is priced at $90 per person, or elevate your experience with wine pairings for each course for $135. This special menu will ONLY be available November 23rd.
    11/23 Morocco "Grows Together/Goes Together" Photo
  • 12/21 Japan "Grows Together/Goes Together"

    $90.00 - $135.00 per person

    Dec 21, 2024 only
    Join us at M Brothers on Saturday, December 21, 2024, for an unforgettable culinary experience! Indulge in a 4-course tasting menu inspired by the vibrant flavors of Japan! This experience is priced at $90 per person, or elevate your experience with wine pairings for each course for $135. This special menu will ONLY be available December 21st.
    12/21 Japan "Grows Together/Goes Together" Photo

What 449 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.8
4.8 based on recent ratings
  • 4.8Food
  • 4.8Service
  • 4.7Ambience
  • 4.5Value

NoiseModerate

Loved For

  • Jacksonville / Northeast Florida

    Best Overall

  • Jacksonville / Northeast Florida

    Best Service

  • Jacksonville / Northeast Florida

    Innovative

  • Jacksonville / Northeast Florida

    Healthy

  • Jacksonville / Northeast Florida

    Seafood

  • Jacksonville

    Best Overall

  • Jacksonville

    Best Food

  • Jacksonville

    Best Service

  • Jacksonville

    Best Value

  • Jacksonville

    Innovative

  • Jacksonville

    Healthy

Review summary

AI-generated from verified diner reviews
M Brothers at Mayo offers an exceptional dining experience right in the heart of Mayo Clinic. Guests rave about the "outstanding" food and service, praising the innovative menu and accommodating staff. The ambiance is both calming and inviting, making it a "hidden gem" for any occasion. A must-visit!

449 Reviews
  1. Racheal

    Jacksonville

    5 reviews

    vip
    3.0

    5 reviews

    Dined 4 days ago

    1. Overall 3
    2. Food 3
    3. Service 4
    4. Ambience 4
    Our server was attentive and kind. Our food took too long to come out from the kitchen. Luckily, our group enjoys spending time with each other.

    Is this helpful?

  2. kayla

    Jacksonville

    1 review

    5.0

    1 review

    Dined on November 4, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Brandon and Dwayne were amazing. Brandon made me a fabulous Dirty Martini and Dwayne recommended two very good bottles of wine for the half off wine Monday. Destanee was a great server and also recommended the Summer Truffle Tagliatelle and Steak Frites. Doug and Dalvin also stopped by our table to make sure everything came out good. Chef Thomas prepared an amazing dessert and all the food was awesome.
    M Brothers at MayoResponded 7 days ago
    Thank you for the kind words! We're so glad to hear Brandon, Dwayne, Destinee, Doug, Dalvin, and Chef Thomas all made your experience memorable. We’ll be sure to pass along your compliments to the team. Hope to see you again soon!

    Is this helpful?

  3. Melanie

    Coastal Georgia

    2 reviews

    5.0

    2 reviews

    Dined on October 31, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    The food here is outstanding. I had to stay on the Mayo campus for several days due to a procedure, and it was so uplifting to be able to go to a 4 star restaurant during my recovery process. The atmosphere was very relaxing and beautiful, the service was impeccable, and my entree, the Salmon Nicoise, was delicious. They also have an extensive wine menu, cocktail menu, and delicious desserts.

    Is this helpful?

  4. max

    Miami

    59 reviews

    vip
    5.0

    59 reviews

    Dined on October 22, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great staff and food always fresh. Ordered the burrata, shrimp po boy and hamburger they were delicious
    M Brothers at MayoResponded on October 23, 2024
    Thank you for the kind words! Our team looks forward to serving you again soon!

    Is this helpful?

  5. Brandi

    Orlando

    3 reviews

    5.0

    3 reviews

    Dined on October 15, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    Great food, great service. Don’t let the idea of a restaurant located in a hospital put you off. Free valet and staff was friendly and engaging. We’ll be back!
    M Brothers at MayoResponded on October 21, 2024
    Thank you for the great review! We're so glad you enjoyed the food and service. We look forward to welcoming you back soon!

    Is this helpful?

  6. Scott

    Jacksonville

    17 reviews

    4.0

    17 reviews

    Dined on October 8, 2024

    1. Overall 4
    2. Food 5
    3. Service 5
    4. Ambience 3
    Excellent service and fare! Great spot if you have to be a Mayo!
    M Brothers at MayoResponded on October 14, 2024
    Thank you for your kind words! We're glad you enjoyed the service and food. We appreciate your recommendation and look forward to welcoming you back!

    Is this helpful?

  7. OpenTable Diner

    Jacksonville

    4 reviews

    5.0

    4 reviews

    Dined on October 5, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 3
    Outstanding dinner and superb service. Slow paced meal. Server found our wine selection. Pleasant atmosphere with a piano player. Wonderful!
    M Brothers at MayoResponded on October 14, 2024
    Thank you for the wonderful feedback! We’re delighted you enjoyed the atmosphere, the piano, and Jessica’s attentive service. We look forward to welcoming you back for another memorable evening!

    Is this helpful?

  8. Brenda

    Jacksonville

    76 reviews

    vip
    5.0

    76 reviews

    Dined on October 5, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Totally enjoyed our evening. Nice ambiance, able to actually have a conversation without yelling, the meal was delicious. Service was perfect and server had a charming personality. We left very happy and highly recommend.
    M Brothers at MayoResponded on October 7, 2024
    Thank you for the wonderful review! We're so glad you enjoyed the ambiance, delicious meal, and charming service. It means a lot that you left happy—can’t wait to welcome you back! 😊

    Is this helpful?

  9. Chauntelle

    San Francisco

    1 review

    vip
    5.0

    1 review

    Dined on October 3, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Everything about this place is fantastic! We had the burrata appetizer with the pesto tomato jam and it was amazing. Every one of the four of us LOVED our lunch!
    M Brothers at MayoResponded on October 7, 2024
    Thank you for the kind words! We're thrilled you loved the burrata appetizer and that everyone enjoyed their lunch. Can’t wait to have you back for more fantastic meals! 🍅✨

    Is this helpful?

  10. Ellwood

    New York City

    13 reviews

    vip
    5.0

    13 reviews

    Dined on September 21, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    The noise level was notably much higher than previous times. A part is due to the numerous hard surfaces. but the piano music was too pronounced
    M Brothers at MayoResponded on September 23, 2024
    Thank you for the feedback and the 5 stars! We’re glad you enjoyed your visit and appreciate your note on the noise level. We'll keep it in mind for future visits. Hope to see you again soon!

    Is this helpful?

FAQs

M Brothers at Mayo is rated 4.8 stars by 449 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a reservation

2 people
11:00 PM
Booked 11 times today
Experiences are available.
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross street
    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.
  • Neighborhood
    Jacksonville
  • Hours of operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Dining style
    Fine Dining
  • Dress code
    Casual Dress
  • Parking details
    Valet
  • Additional
    Bar/Lounge, Chef's Table, Non-Smoking, Private Room
  • Privacy Policy
  • Terms of Use
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable, Inc. 1 Montgomery St Ste 500, San Francisco CA 94104 - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo